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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1928 1
1931 2
1932 2
1933 1
1934 3
1935 1
1936 2
1938 3
1939 4
1940 4
1941 2
1942 6
1943 4
1944 3
1945 14
1946 56
1947 82
1948 69
1949 63
1950 100
1951 79
1952 86
1953 83
1954 104
1955 94
1956 85
1957 72
1958 84
1959 89
1960 86
1961 93
1962 134
1963 245
1964 414
1965 374
1966 387
1967 477
1968 589
1969 700
1970 702
1971 747
1972 857
1973 846
1974 946
1975 932
1976 896
1977 825
1978 819
1979 889
1980 1062
1981 1152
1982 1362
1983 1550
1984 1661
1985 1726
1986 1858
1987 1824
1988 1837
1989 1857
1990 2068
1991 1961
1992 1975
1993 1876
1994 1816
1995 1735
1996 1686
1997 1636
1998 1533
1999 1500
2000 1573
2001 1531
2002 1538
2003 1551
2004 1641
2005 1644
2006 1751
2007 1745
2008 1752
2009 1679
2010 1793
2011 1806
2012 1830
2013 1905
2014 1824
2015 1706
2016 1779
2017 1812
2018 1830
2019 1985
2020 2080
2021 2099
2022 2134
2023 1985
2024 852

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85,853 results

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The following term was ignored: "
The following terms were not found in PubMed: 20044642, 19838924, 16598721, 12484228
Page 1
Glycine and aging: Evidence and mechanisms.
Johnson AA, Cuellar TL. Johnson AA, et al. Ageing Res Rev. 2023 Jun;87:101922. doi: 10.1016/j.arr.2023.101922. Epub 2023 Mar 31. Ageing Res Rev. 2023. PMID: 37004845 Free article. Review.
The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. ...A review of the literature strongly implicates GNMT, which clears methionine from the body by taking a methyl group from S-adenosyl- …
The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. .. …
Methionine deficiency facilitates antitumour immunity by altering m(6)A methylation of immune checkpoint transcripts.
Li T, Tan YT, Chen YX, Zheng XJ, Wang W, Liao K, Mo HY, Lin J, Yang W, Piao HL, Xu RH, Ju HQ. Li T, et al. Gut. 2023 Mar;72(3):501-511. doi: 10.1136/gutjnl-2022-326928. Epub 2022 Jul 8. Gut. 2023. PMID: 35803704 Free PMC article.
DESIGN: The antitumour immunity effect of methionine-restricted diet (MRD) feeding was assessed in murine models. ...Targeting methionine metabolism or YTHDF1 could be a potential new strategy for cancer immunotherapy....
DESIGN: The antitumour immunity effect of methionine-restricted diet (MRD) feeding was assessed in murine models. ...Targeting met …
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade.
Xue Y, Lu F, Chang Z, Li J, Gao Y, Zhou J, Luo Y, Lai Y, Cao S, Li X, Zhou Y, Li Y, Tan Z, Cheng X, Li X, Chen J, Wang W. Xue Y, et al. Nat Commun. 2023 Aug 8;14(1):4758. doi: 10.1038/s41467-023-40518-0. Nat Commun. 2023. PMID: 37553341 Free PMC article.
Whereas, short-term methionine starvation accelerates ferroptosis by stimulating CHAC1 transcription. In vivo, dietary methionine with intermittent but not sustained deprivation augments tumoral ferroptosis. ...
Whereas, short-term methionine starvation accelerates ferroptosis by stimulating CHAC1 transcription. In vivo, dietary methionine …
Dietary methionine starvation impairs acute myeloid leukemia progression.
Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins DA, van den Heuvel FAJ, Wierenga ATJ, Ten Berge H, Dennebos R, van den Boom V, Hogeling SM, Weinhäuser I, Knops R, de Blaauw P, Heiner-Fokkema MR, Woolthuis C, Günther UL, Rego EM, Martens JHA, Jansen JH, Schwalbe H, Huls G, Schuringa JJ. Cunningham A, et al. Blood. 2022 Nov 10;140(19):2037-2052. doi: 10.1182/blood.2022017575. Blood. 2022. PMID: 35984907 Free article.
Reactive oxygen species levels were not increased following methionine depletion, and replacement of methionine with glutathione or N-acetylcysteine could not rescue phenotypes, excluding a role for methionine in controlling redox balance control in AML. Alth …
Reactive oxygen species levels were not increased following methionine depletion, and replacement of methionine with glutathio …
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism.
Upadhyayula PS, Higgins DM, Mela A, Banu M, Dovas A, Zandkarimi F, Patel P, Mahajan A, Humala N, Nguyen TTT, Chaudhary KR, Liao L, Argenziano M, Sudhakar T, Sperring CP, Shapiro BL, Ahmed ER, Kinslow C, Ye LF, Siegelin MD, Cheng S, Soni R, Bruce JN, Stockwell BR, Canoll P. Upadhyayula PS, et al. Nat Commun. 2023 Mar 2;14(1):1187. doi: 10.1038/s41467-023-36630-w. Nat Commun. 2023. PMID: 36864031 Free PMC article.
Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-containing amino acid cysteine, and indirectly from methionine via the transsulfuration …
Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 ( …
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.
Liu I, Jiang L, Samuelsson ER, Marco Salas S, Beck A, Hack OA, Jeong D, Shaw ML, Englinger B, LaBelle J, Mire HM, Madlener S, Mayr L, Quezada MA, Trissal M, Panditharatna E, Ernst KJ, Vogelzang J, Gatesman TA, Halbert ME, Palova H, Pokorna P, Sterba J, Slaby O, Geyeregger R, Diaz A, Findlay IJ, Dun MD, Resnick A, Suvà ML, Jones DTW, Agnihotri S, Svedlund J, Koschmann C, Haberler C, Czech T, Slavc I, Cotter JA, Ligon KL, Alexandrescu S, Yung WKA, Arrillaga-Romany I, Gojo J, Monje M, Nilsson M, Filbin MG. Liu I, et al. Nat Genet. 2022 Dec;54(12):1881-1894. doi: 10.1038/s41588-022-01236-3. Epub 2022 Dec 5. Nat Genet. 2022. PMID: 36471067 Free PMC article.
Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons but are also increasingly recognized in adults. ...
Histone 3 lysine27-to-methionine (H3-K27M) mutations most frequently occur in diffuse midline gliomas (DMGs) of the childhood pons bu …
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.
Jiang C, Liu J, He S, Xu W, Huang R, Pan W, Li X, Dai X, Guo J, Zhang T, Inuzuka H, Wang P, Asara JM, Xiao J, Wei W. Jiang C, et al. Cell Metab. 2023 Dec 5;35(12):2183-2199.e7. doi: 10.1016/j.cmet.2023.11.001. Epub 2023 Nov 24. Cell Metab. 2023. PMID: 38006878
Methionine is an essential branch of diverse nutrient inputs that dictate mTORC1 activation. In the absence of methionine, SAMTOR binds to GATOR1 and inhibits mTORC1 signaling. However, how mTORC1 is activated upon methionine stimulation remains largely elusi …
Methionine is an essential branch of diverse nutrient inputs that dictate mTORC1 activation. In the absence of methionine, SAM …
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota.
Ji M, Xu X, Xu Q, Hsiao YC, Martin C, Ukraintseva S, Popov V, Arbeev KG, Randall TA, Wu X, Garcia-Peterson LM, Liu J, Xu X, Andrea Azcarate-Peril M, Wan Y, Yashin AI, Anantharaman K, Lu K, Li JL, Shats I, Li X. Ji M, et al. Nat Metab. 2023 Sep;5(9):1526-1543. doi: 10.1038/s42255-023-00854-3. Epub 2023 Aug 3. Nat Metab. 2023. PMID: 37537369 Free PMC article.
Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported to repress cancer growth and improve therapeutic responses in several preclinical settings. ...Dietary supplementation of a hydrogen sulfide donor or a precursor, or methionine …
Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported to repress cancer growth and improve ther …
Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells.
Pandit M, Kil YS, Ahn JH, Pokhrel RH, Gu Y, Mishra S, Han Y, Ouh YT, Kang B, Jeong MS, Kim JO, Nam JW, Ko HJ, Chang JH. Pandit M, et al. Nat Commun. 2023 May 5;14(1):2593. doi: 10.1038/s41467-023-38316-9. Nat Commun. 2023. PMID: 37147330 Free PMC article.
Reduced H3K79me2 due to methionine deprivation downregulates AMPK, upregulates PD-1 expression and impairs antitumor immunity in CD4 T cells. Methionine supplementation restores H3K79 methylation and AMPK expression, lowering PD-1 levels. ...
Reduced H3K79me2 due to methionine deprivation downregulates AMPK, upregulates PD-1 expression and impairs antitumor immunity in CD4 …
Contactless edema via plasmin.
Strickland S, Norris EH. Strickland S, et al. Blood. 2024 Feb 15;143(7):570-571. doi: 10.1182/blood.2023023292. Blood. 2024. PMID: 38358851 No abstract available.
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